Table 3.

Associations between the level of humoral Epstein-Barr virus response (anti-EBNA-1 titer) and magnetization transfer ratio outcome measures in multiple sclerosis and healthy controls.

	HCs (n=41)			MS (n=101)
	rs-value	p-value	BH-adjusted p-value	rs-value	p-value	BH-adjusted p-value
T2 lesion MTR	0.087	0.641	0.681	−0.210	0.041	0.087
T1 lesion MTR	-	-	-	−0.287	0.012	0.035
NABT MTR	0.206	0.195	0.237	−0.168	0.095	0.161
NAWM MTR	0.235	0.139	0.186	−0.152	0.132	0.186
NAGM MTR	0.246	0.121	0.186	−0.215	0.032	0.077

HC – healthy controls, MS – multiple sclerosis, BH – Benjamini-Hochberg, MTR – magnetization transfer ratio, NABT – normal appearing brain tissue, NAWM – normal appearing white matter, NAGM – normal appearing gray matter.

Spearman’s ranked correlations (for the HCs) and partial non-parametric correlations adjusted for scanner field strength (for MS) were used. Benjamini-Hochberg-adjusted p values < 0.05 were considered significant.