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. 2019 Aug 13;9:11783. doi: 10.1038/s41598-019-48286-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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WDR-23 interacts with GEN-1. (A) Identification of gen-1 as a potential interactor with wdr-23 through a yeast-2-hybrid screen. (B) GEN-1 co-immunoprecipitates with both WDR-23 isoforms in HEK293T cells overexpressing tagged worm versions of GEN-1-FLAG and GFP-WDR-23. (C) The interaction between GEN1 and both isoforms of WDR23 is conserved in HEK293T cells overexpressing tagged human versions of FLAG-GEN1 and GFP-WDR23. Blocked = blocked magnetic agarose GFP beads. GFP = magnetic agarose GFP beads. Input = 2.5% of whole-cell extract used for IP. U = unbound/flow through fraction. B = bound fraction. αGFP probed for GFP-WDR-23/GFP-WDR23 isoforms. αFLAG for GEN-1-FLAG/FLAG-GEN1.