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. 2019 Aug 13;9:11783. doi: 10.1038/s41598-019-48286-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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WDR-23 isoforms regulate GEN-1 and/or SKN-1 stability and activity. Model for the coordination between the nuclear and cytoplasmic isoforms of WDR-23-mediated regulation of its substrates. Cytoplasmic WDR-23A activity results in activation of substrates, while nuclear WDR-23B drives turnover of substrates to the proteasome. The activity of cytoplasmic (activating) and nuclear (repressive) WDR-23 on its substrates may be linked to mono- or poly-ubiquitination, respectively.