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. 2019 Aug 13;9:11800. doi: 10.1038/s41598-019-48089-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The expression of secretome genes exclusive for ASCs during osteogenesis. (a) Venn diagram representing the comparison of secretome genes between BMSCs and ASCs during osteogenesis. The 177 upregulated secretome proteins includes 46 common genes and 131 genes exclusively found in BMSCs. Similarly, the 67 upregulated proteins includes 46 common genes and 21 genes exclusive to ASCs. (b) Gene ontology functional analysis of upregulated secretome genes in ASCs under biological process category. (c) Representation of the 46 common upregulated genes between ASCs and BMSCs. (d) Twenty one genes were found to be exclusively upregulated in ASCs that were downregulated in BMSCs; Representation of 21 exclusively upregulated secretome genes in ASCs during osteogenesis.