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. 2019 Aug 13;9:11740. doi: 10.1038/s41598-019-47876-0

Table 3.

Suggested algorithm on tacrolimus dosing based on CYP3A5 and the dose of mycophenolate mofetil.

Target trough level of TAC CYP3A5 expressers CYP3A5 non-expressers
MMF 250 mg bid MMF 500 mg bid MMF 750 mg bid MMF 1 g bid MMF 250 mg bid MMF 500 mg bid MMF 750 mg bid MMF 1 g bid
3–4 ng/mL 2 mg bid 1.5 mg bid 1 mg bid 1 mg bid 1 mg bid 1 mg bid 0.5 mg bid 0.5 mg bid
4–5 ng/mL 2.5 mg bid 2 mg bid 2 mg bid 1 mg bid 1.5 mg bid 1 mg bid 1 mg bid 0.5 mg bid
5–7 ng/mL 3 mg bid 2.5 mg bid 2 mg bid 1.5 mg bid 2 mg bid 1.5 mg bid 1 mg bid 1 mg bid

bid, twice daily; CYP3A5 expresser, CYP3A5*1/*1 or CYP3A5*1/*3 carriers; CYP3A5 non-expresser, CYP3A5*3/*3 carriers; MMF, mycophenolate mofetil; TAC, tacrolimus.