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. 2019 Aug 13;6:149. doi: 10.1038/s41597-019-0156-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Translational Research Metadata Framework (TREMF). The domain model (L4) defines the common elements of a translational research project and the relations between them establishing context for exploring data and cross-study comparisons. Different activities (clinical or assays) within a project generate datasets that are modelled according to generic interoperable meta-model (L3). Dataset content (observational data) is modelled against the common observation model (L2): a vector of related data elements each defined according to the ISO/IEC 11179 data definition model part of the standard model for metadata registries (L1).