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. 2019 Aug 13;9:11780. doi: 10.1038/s41598-019-48162-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of DRS test performance in whole transcript data from bacterial and viral diarrhea patients. (A) Boxplot of DRS values using 1-transcript signature (IFI44L). (B) Boxplot of DRS using 2-transcript signature. Dots indicate disease severity. Dots indicate disease severity. (C) ROC curves generated from 2-transcript (blue) and 1-transcript ([IFI44L; green], [FAM89A; red]) DRS with AUC values and 95% CI. We used a t-test to evaluate statistical differences in DRS values between bacterial and viral patients in panels (A,B). The box represents the interquartile range (25^th to the 75^th) containing the middle 50% of the data, the line in the box represents the median, and the whiskers represent the ranges for the bottom 25% and the top 25% of the data values, excluding outliers.