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. 2019 Aug 13;9:11742. doi: 10.1038/s41598-019-48227-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Heat map of significant metabolites obtained from correlation analysis: The heat map constructed with highly correlated metabolites (n = 37), |r| > 0.9. The colors ranging from blue to orange indicates more concentration of metabolites. ETrA acid = 5,8,11-Eicosatrienoic acid; DHA = docosahexaenoic acid; NAAG = N-Acetylaspartylglutamic acid; LysoPC = lysophosphatidylcholine; PI = phosphatidylinositol; TCA = tricarboxylic acid. (B) Summary plot of metabolite set enrichment analysis (MSEA) of highly correlated metabolites: The horizontal bar graph summarizes the metabolic pathways that were significantly enriched by this group of functionally related metabolites (n = 37) during the setting of I/R injury. The color code corresponds to the calculated p-values (red: p = 4 × 10⁻² to white: p = 8 × 10⁻¹).