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. 2019 Aug 13;9:11742. doi: 10.1038/s41598-019-48227-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between clinical parameters and plasma metabolites at baseline: The figure shows the correlation matrix ordered by hierarchical clustering between the important clinical parameters and plasma metabolites at baseline (0 h, time-1). Positive correlations are displayed in green; negative correlations are displayed in pink; blue arrow indicates the clinical factors. Color intensity and the size of the circle are proportional to the correlation coefficients. In the right side of the correlogram, the legend color shows the correlation coefficients and the corresponding colors. Correlations with p-value > 0.05 as computed by Spearman correlations were considered as insignificant and were left blank. Only those metabolites factors (30 metabolites) having more than two significant correlations (p < 0.05) with any of the clinical parameters were used to construct the correlogram. ETrA acid = 5,8,11-Eicosatrienoic acid; DHA = docosahexaenoic acid; LVEF = left ventricular ejection fraction; 1-palmitoyl –GPC = 1-palmitoyl glycerophosphocholine.