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. 2019 Aug 13;9:11791. doi: 10.1038/s41598-019-48071-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Current-voltage (I/V) relationship of the steady-state NALCN current for wild-type (wt) and its CLIFAHDD variant Y578S in differentiated NG108-15 cells. (A) Representative current traces elicited by a membrane voltage step protocol (test pulses from −90 mV to + 30 mV) from a HP at 0 mV, for a mock-transfected cell (top), a NALCN (wt)-transfected cell (middle), a NALCN (Y578S)-transfected cell (bottom). Only the current traces obtained for the test-pulses at −90 mV (in red), −40 mV (in blue), 0 mV (in black) and +20 mV (in orange) are shown. (B) Corresponding I/V relationships for mock transfected cells (black circles, n = 44), NALCN wt (green squares, n = 45) and its pathogenic variant NALCN Y578S (purple triangles, n = 73). Statistical significance was calculated with a Tukey’s multiple comparisons test.