Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 13;9:11791. doi: 10.1038/s41598-019-48071-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Time- and voltage-dependent inactivation of the NALCN current elicited by the wt, Y578S and L509S variants. (A) Voltage step protocol used to elicit representative current traces obtained in the presence of extracellular Na⁺ (B), in the absence of extracellular Na⁺ (C) and the corresponding trace subtraction to isolate the Na⁺-dependent component of the NALCN current (D) for mock-transfected cells (black traces), NALCN-wt-transfected cells (green traces), NALCN-Y578S-transfected cells (purple traces) and NALCN-L509S-transfected cells (blue traces). (E) Inactivation kinetics (time-constant, τ) of the Na⁺-dependent component of the wt (n = 7), NALCN-Y578S (n = 7) and NALCN-L509S (n = 6) currents in the −100 mV to −20 mV range. Statistical significance was calculated with a Tukey’s multiple comparisons test.