Fig. 1.

Intrinsic brain networks may be used to differentiate depressed treatment responders from nonresponders. a The four intrinsic brain networks implicated in MDD (default mode = yellow, salience = blue, central executive = red, and ventromedial reward = green). Networks were generated using [23]. b Connectivity changes commonly reproduced in depressed patients compared to healthy controls (adapted from [24]). Red boxes and lines indicate increased within-network and between-network connectivity, respectively. Blue boxes and lines indicate decreased within-network and between-network connectivity, respectively. c Nodes and connectivity implicated in predicting antidepressant treatment response, colored by intrinsic brain network membership