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Administration of pamidronate after burn injury through preventing bone resorption hypothetically reduces the release of the TGFβ family members from the bone. The reduction of TGFβ family members seems to be responsible for the partial rescue of myotube atrophy. This signaling appears to be due to the reactivation of the anabolic AKT/mTOR pathway and the reduction of the catabolic ubiquitin-dependent pathway.
