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. 2019 Aug 7;10:1866. doi: 10.3389/fimmu.2019.01866

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Copyright © 2019 Zheng, Liang, Xu, Li, Luo, Wu, Li, Tang, Zhong, Chen, Yang, Sun, Zhang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased C5aR1 expression in psoriatic skin lesions in mice. To induce a psoriatic animal model, IMQ was topically applied to the shaved back of wild-type (C5aR1^+/+) mice for 6 days (A–C), or the ears of wild-type (C5aR1^+/+) mice were intradermally injected with IL-23 for 5 days (D–F). Samples were collected and tested for C5aR1 expression (n = 5/group). (A,D) C5aR1 expression in local skin tissues was detected by IHC. (B,E) C5aR1 mRNA levels in skin tissues were analyzed. (C,F) C5aR1 expression in infiltrated cells from skin lesions was measured by FCM. Values are presented as mean ± SEM (n = 5/group). Gating strategy for (C,F), isotype control for (A,D), and negative control of C5aR1 expression was shown in Figure S1. Data are representative of two independent experiments. ^***p < 0.001.