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. 2019 Aug 7;10:1866. doi: 10.3389/fimmu.2019.01866

Figure 4.

Figure 4

Blockage of C5aR1 signaling with C5a receptor antagonist (C5aR1a) attenuated IMQ-induced psoriatic skin inflammation. C5aR1+/+ mice were pre-treated with C5aRa (1 mg/kg) or 0.9% saline for 2 h prior to treatment with IMQ. After IMQ treatment for six consecutive days, digital pictures were obtained and skin samples were collected. (A) Phenotype of IMQ-induced psoriatic skin lesions. The left three mice were pre-treated with saline, while the right four mice were pre-treated with C5aRa. (B) Disease severity was scored as described (n = 5–6/group). (C) H&E staining of psoriatic skin lesions. Scale bar = 20 μm. (D) IHC staining for Ki67 in psoriatic skin lesions. Scale bar = 5 μm. Arrows indicate positively stained cells. Data are representative of at least three independent experiments and each group consisted of more than five mice. *p < 0.05; **p < 0.01.