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. 2019 Aug 7;10:853. doi: 10.3389/fneur.2019.00853

Figure 5.

Figure 5

Inhibition of CD147 reduces lung and plasma IL-17A expression after stroke. (A) Representative flow cytometry strategy for gating and identifying IL-17A-producing γδT cells (R2:CD45+TCR-γδ+CD4−) and CD4+ T cells (R3:CD45+TCR-γδ−CD4+). Lung-infiltrating cell was isolated at 24 h after stroke. (B,C) Quantification of lung IL-17A-producing γδT cells (B) and CD4+ T cells (C) in the indicated groups. n = 6 per group. (D,E) ELISA assay of IL-17A protein concentrations in the lung tissue (D) and plasma (E) at 24 h after stroke. n = 6 per group. n.s. indicates not statistically significant. *P < 0.05. (F) Real-time RT-PCR analysis of mRNA expression of the chemokines (CXCL1 and CXCL2) in the lung after stroke. n = 5 per group. n.s. indicates not statistically significant. *P < 0.05.