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. 2019 Aug 7;9:282. doi: 10.3389/fcimb.2019.00282

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Copyright © 2019 Shang, Deng, Buskermolen, Roffel, Janus, Krom, Crielaard and Gibbs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Commensal, gingivitis, and cariogenic biofilms regulate TLR expression differently. (A) Western blot analysis of TLRs 1-5 and 7-9 indicate the presence or absence of TLR proteins in RHG epithelium after 24 h biofilm exposure. (B) The TLR 2-7 mRNA expression after biofilm exposure. Data represent the average of three independent experiments (each with an intra-experiment duplicate) ± SD; ^*p < 0.05; ^**p < 0.01; ^****p < 0.0001; one-way ANOVA followed by Bonferroni's multiple comparison for comparison between groups.