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. 2019 Aug 7;13:178. doi: 10.3389/fnbeh.2019.00178

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Copyright © 2019 Pegg, Ethridge, Shields, Slavich, Weinberg and Kujawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simple slopes depicting (A) the relationship between social stress exposure and depression at low (-1 SD), mean, and high (+1 SD) residual RewP to social reward, and (B) the relationship between residual RewP to social reward and depression at low (-1 SD), mean, and high (+1 SD) social stress. Lifetime social stress exposure was positively associated with symptoms of depression at all levels of RewP, but with a relatively stronger magnitude of association at low compared to mean and high levels of residual RewP. Reduced RewP residual predicted more depressive symptoms only at a high level of social stress.