Table 1.

Data sources used for the estimation of the economic burden of and years of life lost for influenza‐associated illness in South Africa, 2013‐2015

Data source (DS) number	Data source and description	Input/use in the estimation approach	Ref.
DS1	Projections of the 2011 South Africa census for 2013‐2015.	Population denominators.	14, 15, 16
DS2	National estimates of influenza‐associated illness during 2013‐2015.	Rates of influenza‐associated illness across syndromes (respiratory, circulatory, and non‐respiratory/non‐circulatory), levels of severity (mild, severe and fatal), and healthcare attendance (medically and non‐medically attended).	6
DS3	Laboratory‐confirmed influenza surveillance data among inpatients with SARI and outpatients with ILI at selected surveillance sites during 2013‐2015.	Length of hospitalization and proportion of in‐hospital procedures (ie, admission to ICU, chest X‐rays, oxygen therapy, medications, and laboratory tests) among influenza‐positive patients with SARI. Proportion of medications among influenza‐positive patients with ILI.	Primary data collection
DS4	Hospitalization data from a large private hospital network (NetCare) active in 7/9 provinces.	Length of hospitalization among patients hospitalized with circulatory or non‐respiratory/non‐circulatory syndromes.	17
DS5	Cost of hospitalization and outpatient consultation.	Itemized unit cost (ie, facility fee, consultation, ICU, chest X‐ray, oxygen therapy, medications, and laboratory tests) for hospitalization and outpatient consultation. Cost per patient day equivalent for hospitalization and average outpatient consultation cost.	18, 19, 20, 21 22, 23
DS6	Costing study of laboratory‐confirmed influenza inpatients with SARI and outpatients with ILI at selected surveillance sites during 2014.	Direct medical and non‐medical costs incurred by the patient/caregiver and absenteeism for medically attended illness (out‐of‐pocket expenditures).	Primary data collection
DS7	Community costing survey implemented in 4/9 provinces of South Africa.	Direct medical and non‐medical costs incurred by the patient/caregiver and absenteeism for non‐medically attended illness (out‐of‐pocket expenditures).	24
DS8	Healthcare utilization survey among individuals with SARI or ILI in three South African communities.	Proportion of non‐medically attended illness that sought care with pharmacies or traditional healers.	25, 26
DS9	Minimum wages and unemployment rate.	Indirect cost due to loss of productivity.	27, 28
DS10	Life expectancy for South Africa during 2013‐2015.	Years of life lost.	29

Abbreviations: ICU, intensive care unit; ILI, influenza‐like illness; SARI, severe acute respiratory illness.