Figure 6.

Treatment in vivo with quinic acid (QA) increases glucose‐stimulated insulin release in mouse islets. (a) Experimental schedule. Mice were continuously treated with QA or saline control for 12 weeks using subcutaneously implanted micro‐osmotic pumps. (b) Insulin secretion measured from islets at 2‐ and 20‐mM glucose isolated from mice implanted with QA‐loaded minipump. (c) Insulin content of the islets normalized to islet number. White bars, controls; black bars, QA pump. (b, c) Data shown are individual values with means ± SEM from n = 5 experiments. *P <.05, significantly different as indicated; one‐way ANOVA