Figure 7.

Quinic acid (QA) improves glucose tolerance. Proposed model for QA‐dependent activation of beta‐cells. (a) Glucose tolerance test and (b) insulin tolerance test in mice fed with chow diet supplemented with QA (25 mg·kg⁻¹·day⁻¹) or with chow diet alone for 2 months. Summary data shown at 45 min are individual values with means ± SEM from n = 9–8 mice for each group. *P <.05, significantly different from vehicle group; Student's t test. (c) Proposed model for QA‐dependent activation of beta‐cells. QA boosts intracellular Ca²⁺ rise in pancreatic beta‐cells, promoting mitochondrial activation. Following glucose stimulation, QA can potentiate, in beta‐cell mitochondria, two matrix Ca²⁺‐dependent processes (oxidative metabolism and ATP synthase‐dependent respiration), which promotes robust insulin secretion