Figure 5.
MN‐08 improved neurological scores and lowered bleeding grades after SAH in a rat model. (a) Diagram of endovascular puncture model of SAH. (b) The timeline of this study, rats were treated with MN‐08 (3, 6, and 12 mg·kg−1), memantine (MEM; 10 mg·kg−1), nimodipine (NIM; 0.1 mg·kg−1), or vehicle control (saline) via intravenous injection at 3 and 6 hr after SAH surgery. On Days 2–7, drugs were administered at 9:00 a.m. and 3:00 p.m. (c) Representative photography after endovascular perforation and sham surgery. (d) Effect of MN‐08 on the SAH bleeding grade. (e) Effect of MN‐08 on the neurological score of SAH rats. Data shown are means ± SEM (n = 7 for sham, model, MN‐08 [6 mg·kg−1], memantine and nimodipine groups; n = 8 for MN‐08 [3 mg·kg−1] and MN‐08 [12 mg·kg−1] groups). # P < .05, significantly different from sham group; *P < .05, significantly different from model group; non‐parametric Kruskal–Wallis test followed by Dunn's multiple comparisons