Figure 8.
MN‐08 attenuated cerebral vasospasm in rabbits after SAH. (a) Schematic diagram of single blood injection SAH model. (b) The timeline of this study, rabbits were treated with MN‐08 (6 mg·kg−1), memantine (MEM; 5 mg·kg−1), nimodipine (NIM; 0.05 mg·kg−1), or vehicle control (saline) via intravenous injection at 3 and 6 hr after SAH surgery. On Days 2–3, drugs were administered at 9:00 a.m. and 3:00 p.m. (c) Representative H&E‐stained cross sections of the basal artery in rabbits after SAH. Scale bars: 50 μm; magnification, ×200. (d) Semi‐quantification of the internal perimeter of lumen, (e) cross‐sectional area of internal lumen, and (f) wall thickness of the basilar artery. Data shown are means ± SEM (n = 6 for sham, model, MN‐08, and memantine groups; n = 5 for nimodipine group). # P < .05, significantly different from sham group; *P < .05, significantly different from model; one‐way ANOVA and Dunnett's multiple comparisons test