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. 2019 Jul 8;10(17):4017–4030. doi: 10.7150/jca.28163

Figure 5.

Figure 5

Construction of the tumor migratory microenvironment and the effect of NRP1 on relevant chemokine secretion and migration of A549 cells. A549 and HLF-1 cells were observed under bright field conditions for 2D and 3D co-culture morphological changes (A). The effect of NRP1 on the secretion of chemokine factors in the migratory microenvironment of lung cancer cells: RANTES (B); MCP-1 (C); CXCL8 (D); IR-10 (E). *p<0.05, ***p<0.001 vs control group; ^p<0.05, ^^^p<0.001 vs A549 group (n=3). Effect of NRP1 on migration of A549 cells in the tumor migratory microenvironment (F). ***p<0.01 vs control; ###p<0.01 vs A549 secretion; &&&p<0.01 vs A549 co-culture (n=5).