Table 3.
Correlation between KPNA3 and clinicopathological characteristics.
| Clinical characteristics | No. of Patients (n=78) |
KPNA3low (n=43) |
KPNA3high (n=35) |
P | |
|---|---|---|---|---|---|
| Age, years | ≤50 | 36 | 22 | 14 | 0.325 |
| >50 | 42 | 21 | 21 | ||
| Sex | Female | 9 | 4 | 5 | 0.493# |
| Male | 69 | 39 | 30 | ||
| ALT, U/L | ≤40 | 39 | 22 | 17 | 0.105 |
| >40 | 39 | 21 | 18 | ||
| HBsAg | Negative | 7 | 1 | 6 | 0.023# |
| Positive | 71 | 42 | 29 | ||
| AFP, ng/ml | ≤400 | 35 | 23 | 12 | 0.090 |
| >400 | 43 | 20 | 23 | ||
| Child-Pugh score | A | 62 | 37 | 25 | 0.112 |
| B | 16 | 6 | 10 | ||
| Tumor size, cm | ≤5 | 39 | 26 | 13 | 0.040 |
| >5 | 39 | 17 | 22 | ||
| PVTT | No | 60 | 34 | 26 | 0.618 |
| Yes | 18 | 9 | 9 | ||
Abbreviations: KPNA3, Karyopherin Subunit Alpha 3; ALT, alanine aminotransferase; AST, aspartate transaminase; AFP, α-fetoprotein; HBsAg, Hepatitis B surface antigen; PVTT, portal vein tumor thrombosis. # indicated Fisher exact tests.