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. 2019 Jul 10;10(17):4123–4131. doi: 10.7150/jca.30883

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Fig 3 — The Kaplan-Meier survival curves of the activated-Shh-pathway group and the integrated model group. Patients with Gli1^high and SMO^high were classified in the activated-Shh-pathway^strong group; all others were assigned to the activated-Shh-pathway^weak group. A) Overall survival curves based on the level of activation of the Shh pathway. B) Recurrence-free survival curves based on the level of activation of the Shh pathway. The integrated model group consists of three subgroups: group I, activated-Shh-pathway^weak/SMAD4^intact; group II, activated pathway^weak/SMAD4^lost or activated-Shh-pathway^strong/SMAD4^intact; group III, with activated-Shh-pathway^strong /SMAD4^lost. C) Overall survival curves based on the integrated model subgroups. D) Recurrence-free survival curves based on the integrated model subgroups. 'p' values were calculated by log-rank test.