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. 2019 Jul 10;176(17):3236–3249. doi: 10.1111/bph.14756

Figure 2.

Figure 2

The effect of ENT1 knockdown by siRNA or OAT2 overexpression in HL7702 cells on the accumulation of ETV. hENT1 mRNA expression (a) and ETV uptake (b) in HL7702 cells transfected with hENT1‐siRNA (s1 and s2) and control siRNA for the time indicated. n = 5. *P < .05 in comparison with the vector. (c) The mRNA expression of hOAT2 in HL7702 cells transfected with hOAT2‐pEnter and corresponding vector for 48 hr. (d) Accumulations of cGMP (OAT2 probe substrate) and ETV in HL7702 cells transfected with hOAT2‐pEnter and corresponding vector for 48 hr in the absence or presence of Indo (OAT2 inhibitor). n = 5. *P < .05 in comparison with vector group; # P < .05 in comparison with ETV‐alone group