Table 4.

Decomposition of the Treatment Effect on Quality of Life Scores for Social Functioning Into Direct Effect and Mediated and Interactive Effects Due to Weight Gain (M₁), Positive and Negative Syndrome Scale Total Symptoms (M₂), and Extrapyramidal Symptoms (M₃), Using Data From the Clinical Antipsychotic Trials of Intervention Effectiveness, United States, 2000–2004

Component	Estimate	95% CI
CDE	−0.63	−1.68, 0.41
PNIEWG	0.81	0.20, 1.58
PNIEPANSS+	0.00	0.16, 0.17
PNIEEPS	0.35	0.05, 1.11
INTrefA·WGb	−0.18	−0.90, 0.33
INTmedA·WGb	−0.85	−1.67, −0.20
NDE	−0.81	−2.10, 0.34
NIE	0.35	−0.26, 1.20
TE	−0.45	−1.45, 0.51

Abbreviations: CDE, controlled direct effect; CI: confidence interval; EPS, extrapyramidal symptoms; INTref, defined reference interaction; INTmed, defined mediated interaction; NDE, natural direct effect; NIE, natural indirect effect; PANSS, Positive and Negative Syndrome Scale; PNIE, pure natural indirect effect; TE, total effect.

^a Bootstrap 95th percentile CI.

^b PNIE_WG·_PANSS+, PNIE_WG·_EPS, PNIE_PANSS+·_EPS, PNIE_WG·_PANSS+·_EPS null because no mediator-mediator interaction. INTref_A·_PANSS+, INTref_A·_EPS, INTref_A·_WG·_PANSS+, INTref_A·_WG·_EPS, INTref_A·_PANSS+·_EPS, INTref_A·_WG·_PANSS+·_M3, INTmed_A·_PANSS+, INTmed_A·_EPS, INTmed_A·_WG·_PANSS+, INTmed_A·_WG·_EPS, INTmed_A·_PANSS+·_EPS, INTmed_A·_WG·_PANSS+·_EPS null because no interaction between treatment and positive PANSS and EPS symptoms and no 3- or 4-way interactions.

^c NDE = CDE + INTref term.

^d NIE = PNIE terms + INTmed term.

^e TE = NDE + NIE.