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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Ann Neurol. 2019 May 13;86(1):116–128. doi: 10.1002/ana.25492

Figure 4: Modelling the effect of early diagnosis by NBS for age-matched preschool children with ASS1-D (n=21) and ASL-D (n=27).

Figure 4:

Descriptive characteristics are presented separately in Table 1. NBS improves cognitive outcome for ASS1-D (p<0.001, ANOVA post-hoc comparison) and ASL-D individuals (p=0.021, ANOVA post-hoc comparison). Gray lines are fitted cSDS values from the linear model; the gray shaded area corresponds to 95% CI. NBS, newborn screening. SX, selective metabolic investigation after the onset of symptoms.