Metropolitan area temporal trends in air pollution exposures are shown based on annual mean concentrations for all participants in each area from continuous 2-week average concentrations from 2000 through follow-up. The exposure data included 1037 participants in Winston-Salem, NC; 1182 in New York, NY, and Rockland County, NY; 1054 in Baltimore, MD; 1021 in St Paul, MN; 1142 in Chicago, IL; and 1424 in the Los Angeles Basin area.