Table 1. Characteristics of Participants in the Magnetic Resonance Imaging Substudy.
| Variable | Completed Baseline Scan | Completed Follow-up Scan | ||
|---|---|---|---|---|
| Intensive Treatment (n = 355) | Standard Treatment (n = 315) | Intensive Treatment (n = 249) | Standard Treatment (n = 200) | |
| Age, mean (SD), y | 67.7 (8.0) | 66.9 (8.5) | 67.8 (7.7) | 66.3 (7.8) |
| Age ≥75 y, No. (%) | 83 (23.4) | 67 (21.3) | 55 (22.1) | 36 (18.0) |
| Sex, No. (%) | ||||
| Men | 200 (56.3) | 199 (63.2) | 151 (60.6) | 131 (65.5) |
| Women | 155 (43.7) | 116 (36.8) | 98 (39.4) | 69 (34.5) |
| Black race, No. (%)a | 116 (32.7) | 106 (33.7) | 71 (28.5) | 67 (33.5) |
| Race/ethnicity, No. (%) | ||||
| White | 222 (62.5) | 184 (58.4) | 169 (67.9) | 118 (59.0) |
| Black | 114 (32.1) | 104 (33.0) | 69 (27.7) | 65 (32.5) |
| Hispanicb | 14 (3.9) | 22 (7.0) | 9 (3.6) | 13 (6.5) |
| Otherc | 5 (1.4) | 5 (1.6) | 2 (0.8) | 4 (2.0) |
| History of CVD, No. (%) | 48 (13.5) | 45 (14.3) | 31 (12.4) | 21 (10.5) |
| Systolic BP, mean (SD), mm Hg | 138.2 (17.6) | 137.8 (15.5) | 136.0 (17.0) | 138.2 (15.8) |
| Tertile, No. (%) | ||||
| ≤129 | 130 (36.6) | 99 (31.4) | 96 (38.6) | 63 (31.5) |
| >129 to <143 | 102 (28.7) | 105 (33.3) | 77 (30.9) | 67 (33.5) |
| ≥143 | 123 (34.6) | 111 (35.2) | 76 (30.5) | 70 (35.0) |
| Diastolic BP, mean (SD), mm Hg | 77.3 (10.9) | 78.5 (12.0) | 76.5 (10.7) | 79.3 (12.1) |
| Orthostatic hypotension, No. (%)d | 26 (7.3) | 17 (5.4) | 20 (8.0) | 15 (7.5) |
| eGFR, mean (SD), mL/min/1.73 m2,e | 72.0 (20.0) | 72.6 (21.3) | 71.7 (19.2) | 73.3 (20.7) |
| eGFR <60 mL/min/1.73 m2, No. (%)e | 94 (26.6) | 90 (28.7) | 66 (26.5) | 55 (27.5) |
| Montreal Cognitive Assessment, median (IQR)f | 24 (21-26) | 24 (21-26) | 24 (21-27) | 24 (22-27) |
| Intracranial volume, mean (SD), cm3 | 1372.1 (148.3) | 1391.7 (145.1) | 1384.3 (142.3) | 1398.6 (146.7) |
| Total brain volume, mean (SD), cm3 | 1126.9 (113.6) | 1141.0 (114.7) | 1136.7 (110.4) | 1150.5 (113.2) |
| WML volume, median (IQR), cm3 | 3.0 (1.5-6.2) | 3.3 (1.6-6.2) | 2.9 (1.5-5.9) | 3.2 (1.7-6.2) |
| Transformed WML volume, mean (SD), asinh(cm3) | 2.0 (1.0) | 2.0 (1.0) | 2.0 (1.0) | 1.9 (0.9) |
Abbreviations: BP, blood pressure; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; IQR, interquartile range; WML, white matter lesion; asinh, inverse hyperbolic sine transformation, f(x) = log(x + (x2 + 1)0.5).
Black race includes Hispanic black and black as part of multiracial identification.
Hispanic race/ethnicity encompasses a self-report of being of Spanish, Hispanic, or Latino origin, independent of any other race/ethnicity designation.
Includes categories of Asian, American Indian/Alaskan Native, Native Hawaiian/Pacific Islander, or other.
Defined as a value of −20 mm Hg or less for standing systolic BP minus seated systolic BP or of −10 mm Hg or less for standing diastolic BP minus seated diastolic BP.
Based on the 4-variable Modification of Diet in Renal Disease equation.
Scores range from 0 to 30, with higher scores denoting better cognitive function.