. 2019 Apr 17;317(1):F43–F51. doi: 10.1152/ajprenal.00083.2019

Table 1.

Mean bladder pressures during open-outlet, conscious cystometry before and after Ki-8751 infusion in no CYP control, acute CYP, and chronic CYP male and female rats

	Threshold Pressure, cmH₂O	Minimum Pressure, cmH₂O	Average Pressure, cmH₂O	Maximum Pressure, cmH₂O
Female rats
Control
Before Ki-8751	13.2 ± 0.9	10.2 ± 0.8	13.1 ± 1.3	35.5 ± 3.8
After Ki-8751	14.1 ± 0.9	8.4 ± 0.3	12.0 ± 0.5	36.5 ± 3.6
4-h CYP
Before Ki-8751	21.0 ± 3.7	16.7 ± 3.0	19.0 ± 3.2	43.9 ± 5.9
After Ki-8751	18.6 ± 3.1	14.4 ± 2.5	16.6 ± 2.7	41.0 ± 6.2
Chronic CYP
Before Ki-8751	37.4 ± 7.2	25.6 ± 6.2	30.2 ± 6.7	71.5 ± 9.7
After Ki-8751	36.8 ± 5.0	22.5 ± 3.9	28.1 ± 4.7	73.5 ± 6.7
Male rats
Control
Before Ki-8751	12.8 ± 1.1	9.0 ± 0.8	11.4 ± 1.1	40.9 ± 3.6
After Ki-8751	12.6 ± 0.9	8.3 ± 1.0	10.5 ± 1.0	35.3 ± 3.7
4-h CYP
Before Ki-8751	16.3 ± 0.3	12.6 ± 0.4	14.3 ± 0.4	41.2 ± 2.1
After Ki-8751	16.2 ± 1.0	11.3 ± 0.5	13.9 ± 0.6	40.0 ± 2.3
Chronic CYP
Before Ki-8751	32.3 ± 2.5	23.0 ± 2.2	26.6 ± 2.3	61.8 ± 3.4
After Ki-8751	22.7 ± 1.1^†	13.6 ± 1.1^†	16.3 ± 1.3^*	52.7 ± 4.2

Values are means ± SE; n = 6–8 rats/group. CYP, cyclophosphamide. A paired, two-tailed Student’s t-test was used to compare urinary bladder pressure parameters before versus after infusion of Ki-8751. Significant difference between before and after Ki-8751 infusion:

P ≤ 0.05 and

^†

P ≤ 0.01.