Fig. 1.

Effects of major basic protein (MBP; A) and vehicle (Veh; B) treatments on cough response to SO₂ inhalation challenge in awake mice. Left: representative experimental records of coughs evoked during the SO₂ (600 ppm) inhalation challenge. P_cham, pressure inside the recording chamber; P_ip, intrapleural pressure recorded by telemetry. Middle and right: group data of cough responses to SO₂ inhalation challenges (300 and 600 ppm, respectively, marked by shaded areas) before (average of 3 consecutive days) and on the second day after MBP or Veh treatment. Data are means ± SE (n = 8 in each group).