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. 2019 Aug 7;13:817. doi: 10.3389/fnins.2019.00817

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Copyright © 2019 Schneider, Spritzer, Minuzzi, Frey, Syan, Fighera, Schwarz, Costa, da Silva, Garcia, Fontanari, Real, Anes, Castan, Cunegatto and Lobato.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plots showing changes in whole-brain functional connectivity after a minimum of 60 days of estradiol therapy using multivoxel pattern analysis. (A) Plots individual changes in FC between the cluster within the subcallosal cortex and the rest of the brain. (B) Shows group average changes in FC (–19.51) between time points, with a 90% confidence interval (C.I: –25.4 to –13.52). Cluster size p-FDR <0.0013.