TABLE 1.
Clinical and laboratory characteristics of the sample.
| Clinical and laboratory characteristics of the sample | |||
| Age (years, mean/sd) | 41.59 (8.66) | ||
| Age beginning CSHT (years, mean/sd) | 22 (7.98) | ||
| Lifetime exposure to CSHT (years, mean/sd) | 17.71 (8.62) | ||
| Time post-GAS (years, median/IqI) | 2 (1–4) | ||
| Time off CSHT (days, mean/sd) | 35.86 (3.32) | ||
| Time on CSHT after t1 (days, mean/sd) | 66.1 (5.49) | ||
| Handedness (mean/sd) | 98.94 (4.36) | ||
| t1 | t2 | p-value | |
| E2 pg/mL (median/IqI) | <5.0 (0–0) | 93.23 (25.8–135.30) | 0.0002* |
| Testosterone ng/mL (mean/sd) | 0.07 (0.10) | 0.11 (0.15) | 0.43 |
| LH mIU/mL (mean/sd) | 50.85 (22.01) | 30.7 (22.99) | 0.10 |
| FSH mIU/mL (mean/sd) | 91.75 (38.01) | 56.56 (33.61) | 0.02* |
| HAM-D (median/IqI) | 4.0 (1–10) | 2 (1–6) | 0.51 |
| HAM-A (median/IqI) | 5 (1–12) | 2 (1–10) | 0.16 |
Pre and post comparisons were done with paired t-test or Wilcox test. Interpretation of handedness scale: scores <−40 indicates predominantly left handed; scores between −40 and +40 indicates ambidextrous; scores >+40 indicate predominantly right handed. GD, gender dysphoria; CD, cross-dressing; CSHT, cross-sex hormone therapy; SHBG, sex hormone binding globulin; LH, luteinizing hormone; FSH, follicle-stimulating hormone; DHEA-S, dehydroepiandrosterone sulfate; FSIQ, full-scale intelligence quotient; HAM-D, hamilton depression rating scale; HAM-A, hamilton anxiety rating scale; IqI, interquartile interval; sd, standard deviation; t1: washout, t2, CSHT conditions; *, significant at p < 0.05.