TABLE 2.

Region-of-Interest to Region-of-Interest analysis.

Seed	Target	Beta	T (14)	p-unc	p-FDR
L thalamus
	L lateral sensorimotor	0.20	3.86	0.002	0.016*
	R lateral sensorimotor	0.13	2.62	0.020	0.060
	S sensorimotor	0.06	0.93	0.286	0.474
	L putamen	0.14	3.26	0.006	0.026*
	R putamen	0.06	0.94	0.264	0.474
	L caudate	0.13	1.49	0.158	0.356
	R caudate	0.10	1.17	0.262	0.472
	L pallidum	0.05	0.76	0.458	0.516
	R pallidum	0.03	0.66	0.519	0.519
R thalamus	L lateral sensorimotor	0.20	2.87	0.012	0.086
	R lateral sensorimotor	0.17	2.65	0.191	0.086
	S sensorimotor	0.04	0.73	0.475	0.590
	L putamen	0.10	1.61	0.130	0.292
	R putamen	0.06	1.30	0.187	0.337
	L caudate	0.06	0.73	0.475	0.590
	R caudate	0.09	1.10	0.290	0.435
	L pallidum	0.11	2.31	0.036	0.109
	R pallidum	–0.03	–0.45	0.658	0.658

Estimated connectivity differences in the resting-state functional connectivity comparing estradiol and washout time points (t2 > t1). Analyses were controlled for age differences and changes in anxiety scores according to the Hamilton Inventory. Beta indicates the average difference on the connectivity values across the regions of interest. L, left; R, right; S, superior; Rs-FC, resting-state functional connectivity; unc, uncorrected for multiple comparisons; FDR, false discovery rate; ^*, statistical significance after FDR <0.05.