Table 1. Analytical Data of the Synthesized POx-Ale Polymers and the Conversion of Alendronate Functionalization.
|
1H NMR (mol %) |
Mn (kDa) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| polymer | EtOx/PropOx | OH | COOH | Ale | conversion (%) | theor.a | MALDI-TOF MS | Đ | |
| P1e | P(EtOx-Ale) | 90 | 1 | 9 | 90 | 12.8 | 12.0 | 1.11 | |
| P2e | P(EtOx-Ale) | 80 | 1 | 19 | 95 | 15.8 | 15.0 | 1.17 | |
| P3e | P(EtOx-Ale) | 70 | 2 | 28 | 93 | 19.1 | 19.5 | 1.11 | |
| P6e | P(EtOx-OH-Ale) | 70 | 21 | 1 | 8 | 89 | 13.1 | 12.6 | 1.11 |
| P7e | P(EtOx-OH-Ale) | 70 | 12 | 2 | 16 | 89 | 15.5 | 14.6 | 1.11 |
| P10e | P(EtOx-COOH-Ale) | 70 | 17 | 13 | 100 | 15.9 | 16.3 | 1.11 | |
| P11e | P(EtOx-COOH-Ale) | 70 | 10 | 20 | 100 | 17.4 | 16.3 | 1.11 | |
| P4e | P(PropOx-Ale) | 90 | 1 | 9 | 90 | 13.4 | 12.2 | 1.08 | |
| P5e | P(PropOx-Ale) | 70 | 3 | 27 | 90 | 20.4 | 17.5 | 1.12 | |
| P8e | P(PropOx-OH-Ale) | 70 | 20 | 1 | 9 | 90 | 14.7 | 12.8 | 1.12 |
| P9e | P(PropOx-OH-Ale) | 70 | 10 | 3 | 17 | 85 | 17.4 | 17.9 | 1.12 |
| P12e | P(PropOx-COOH-Ale) | 70 | 22 | 8 | 80 | 16.3 | 14.8 | 1.12 | |
| P13e | P(PropOx-COOH-Ale) | 70 | 10 | 20 | 100 | 18.9 | 17.0 | 1.12 | |
a
Theoretical values were calculated considering the polymerization degree of MestOx-functionalized polymers obtained by MALDI-TOF MS and the ratios of the different moieties obtained by 1H NMR spectroscopy.