Table 1.
Transcription factors and niche components identified in the pituitary progenitor compartment.
| Marker | Gene Name | Reference |
|---|---|---|
| Transcription factors | ||
| Sox2 | SRY-box containing gene 2 | [3, 4, 9] |
| Sox9 | SRY-box containing gene 9 | [1, 2, 4, 9, 96] |
| Prop1 | Prophet of Pit1, paired-like homeodomain transcription factor | [2, 12–16] |
| Grhl2 | Grainyhead like transcription factor 2 | [26] |
| Oct4 (Pou5f1) | Octamer-binding protein 4 | [1, 2, 97] |
| Prrx1 | Paired related homeobox protein 1 | [98, 99] |
| Prrx2 | Paired related homeobox protein 2 | [98, 99] |
| Ctnnb1 (β- Catenin) | Cadherin-associated protein beta | [100, 101] |
| Notch signaling components | ||
| Hes1 | Hairy and enhancer of split 1 | [22, 23, 28, 102] |
| Hey1 | Hairy/enhancer-of-split related with YRPW motif 1 | [28, 97] |
| Dll1 | Delta like canonical Notch ligand 1 | [15, 22, 23, 28] |
| Jag1 | Jagged 1 | [97, 102] |
| Notch1 | Notch 1 | [1, 97, 102] |
| Notch2 | Notch 2 | [15, 22, 23, 28, 97, 102] |
| Notch3 | Notch 3 | [23, 97, 102] |
| Extracellular receptors/cell surface antigens | ||
| Ly6a (Sca1) | Stem cell antigen 1 | [1, 97, 102] |
| SSEA-4 | Stage-specific embryonic antigen-4 | [2] |
| Cxadr | Coxsackievirus and adenovirus receptor | [2, 103] |
| Cxcr4 | C-X-C motif chemokine receptor 4 | [97, 103, 104] |
| Lgr5 | Leucine rich repeat containing G protein-coupled receptor 5 | [97] |
| CD44 | CD44 antigen | [97] |
| Gfra2 | GDNF family receptor alpha 2 | [2] |
| Cellular adhesion molecules | ||
| Cdh1 (E-cadherin) | Calcium-dependent adhesion protein | [2, 9, 26] |
| Lama5 (Laminin 5α) | Laminin subunit alpha 5 | [39] |
| Itgb1 (Integrin 1β) | Integrin subunit beta 1 | [104] |
| Other | ||
| S100b | S-100 protein subunit beta | [1, 2, 9, 16, 20, 103] |
| Nestin | Nestin | [1, 97] |