Figure 7.
Alignments of vertebrate IGF1 E peptides. (A) Amino acid sequences of C-terminal common E (16 amino acids) and EA peptides (19 residues) in eight terrestrial vertebrates, coelacanth, human, 11 ray-finned fish, and lamprey in single-letter code. Differences are indicated, with identities depicted by dots. The number of amino acids is listed in parentheses if it differs from 16 residues for the common E region or from 19 residues for EA peptides. (B) Amino acid sequences of C-terminal EB peptides in 11 ray-finned fish, lamprey, and human in single-letter code. Differences are indicated, with identities depicted by dots. A dash indicates no residue. The number of amino acids is listed in parentheses. Blue text depicts amino acid identities between the chicken in (A) and the tetraodon in (B), and red text indicates differences. The asterisk in front of the cave fish heading depicts the presence of an alternate EB peptide with 26 fewer N-terminal amino acids. AA, amino acid.