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. Author manuscript; available in PMC: 2020 Jun 17.
Published in final edited form as: Chem Res Toxicol. 2019 Apr 10;32(6):1151–1164. doi: 10.1021/acs.chemrestox.9b00006

Figure 5.

Figure 5.

Steady-state kinetic profiles for terbinafine N-dealkylation in Pathway 3. CYP2C19 (○) and 3A4 (□) metabolism of terbinafine yielded kinetics for 1-naphthaldehyde in Pathway 3, as shown in Figure 1. The sets of data were fit best to the Michaelis−Menten equation (p < 0.05), and the corresponding constants reported in Tables 1 and 2. A total of 12 experimental reactions were carried out with terbinafine as substrate. Error bars denote the standard deviations. Reaction conditions and data analyses were carried out as described in Experimental Procedures.