Table 4:

Validation metrics for our multi-compartment models against experimental data.

Aβ-Fiber
Parameter	Our Value:	Literature Ranges	Reference
Soma AP amplitude	107.7 mV	109.72 +/− 11.21 mV	(Huxley and Stämpfli 1951; Amir and Devor 2003)
AP duration	1.225 ms	1.29 +/− 0.59 ms	(Harper and Lawson 1985b)
Rise time	0.775 ms	0.61 +/− 0.13	(Djouhri et al. 1998)
Fall time	0.45 ms	0.89 +/− 0.41	(Djouhri et al. 1998)
AHP amplitude	4.2 mV	7.9 +/− 4.2 mV	(Harper and Lawson 1985b)
AHP half-amplitude duration	14.7 ms	10.1 +/− 11.0 ms	(Villière and McLachlan 1996)
Resting potential	−79.1 mV	−80 mV	(Howells et al. 2012)
Ectopic spiking frequency	28 Hz	10–50 Hz	(Amir et al. 2005)
CV (peripheral axon)	25.00 m/s	14–30 m/s	(Harper and Lawson 1985a)
CV (central axon)	17.02 m/s	14–30 m/s	(Harper and Lawson 1985a)
C-Fiber
Parameter	Our Value:	Literature Ranges	Reference
Soma AP amplitude	76.5 mV	81.6 +/− 6.9	(Harper and Lawson 1985b)
AP duration (base)	3.5 ms	4.97 +/− 2.16	(Harper and Lawson 1985b)
Rise time	1.675 ms	2.5 +/− 0.89	(Djouhri et al. 1998)
Fall time	1.825 ms	4.61 +/− 3.5	(Djouhri et al. 1998)
Resting potential	−55 mV	−48.6 +/− 9.2	(Harper and Lawson 1985b)
AHP amplitude	10.9 mV	8.2 +/− 5.1 mV	(Harper and Lawson 1985b)
AHP 80	9.5 ms	14.4 +/− 9.2 ms	(Djouhri et al. 1998)
AHP half-amplitude duration	5.2 ms	12.87 +/− 8.4 ms	(Harper and Lawson 1985b)
CV (peripheral axon)	0.28 m/s	0.2–0.8 m/s	(Zhang et al. 1998)
CV (central axon)	0.21 m/s	0.2–0.8 m/s	(Zhang et al. 1998)
CV (stem axon)	0.39 m/s	0.2–0.8 m/s	(Zhang et al. 1998)

Abbreviations: AP, action potential; AHP, afterhyperpolarization; CV, conduction velocity.