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Predicted allosteric ternary complex model for E2 and 27-OHC binding to human ERβ. The affinities of E2 (KdE2) and 27-OHC (Kd27) for ERβ are modified by the allosteric effects [cooperativity factor (α)] of each other’s binding. When both ligands are binding simultaneously, their affinities for ERβ are given by the functions KdE2/α and Kd27/α.
