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. 2019 Aug 13;17:92. doi: 10.1186/s12964-019-0415-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Expression of RasGRP4 in lymphoma and normal tissues. (a) RasGRP4 was the most abundantly expressed protein among the RasGRP family members in lymphoma. (b) Representative images of the expression of RasGRP4 in DLBCL, FL, and Burkitt lymphoma, which was higher than in reactive lymph nodes. DLBCL showed the highest expression level. Scale bars: 1000 μm (above), 125 μm (below). (c) Representative WB images showing that the expression of RasGRP4 protein was significantly higher in DLBCL patients than in controls. (d and e) Representative images showing that RasGRP4 expression was higher in SUDHL-4 and Raji cell lines compared with normal/activated B cells, as determined by flow cytometry and WB. N indicates the number of independent experiments. **P < 0.01