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. 2019 Aug 7;10:1865. doi: 10.3389/fimmu.2019.01865

Figure 3.

Figure 3

IL-21 promotes CD4+ T cell proliferation and Th17 cell differentiation, whereas inhibits Treg cell differentiation. (A–B) CFSE labeled CD4+ T cells from normal people (n = 8) and psoriasis patients (n = 12) were treated with or without IL-21 (50 ng/ml) for 3 days. (A) Showed a representative result of flow cytometry of psoriasis patients. (C) RORγt and Foxp3 mRNA expression of CD4+ T cells of normal people (n = 15) and psoriasis patients (n = 30) treated with or without IL-21 (50 ng/ml). (D–E) The proportion of Th17 cells (CD4+ IL-17A+ cells) in CD4+ T cells of normal people (n = 15) and psoriasis patients (n = 30) treated with or without IL-21 (50 ng/ml) for 3 days. (D) Showed a representative result of FACS of psoriasis patients. (F–G) The proportion of Treg cells (CD4+, CD25+, and Foxp3+ cells) in CD4+ T cells of normal people (n = 15) and psoriasis patients (n = 30) treated with or without IL-21 (50 ng/ml) for 3 days. (F) Showed a representative FACS result of normal people. Data show means + SD. P-values were determined by paired Student's t-test. *P < 0.05, **P < 0.01, ****P < 0.0001.