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Summary of IL-21 actions in psoriatic inflammation. Under the psoriatic inflammatory microenvironment, CD4+ T cells secret abundant IL-21. Then IL-21 acts on CD4+ T cells via IL-21R to increase RORγt expression and decrease Foxp3 expression, resulting in imbalance of Th17 and Treg cells and increased expression of IL-17A and IL-22, further aggravating the inflammatory microenvironment of psoriasis.
