Fig. 2.1.

Immunologic composition of the T cell-inflamed versus non-T cell-inflamed tumor microenvironments. The T cell-inflamed tumors contain variable numbers of CD8⁺ T cells and CD8α/CD103-lineage DCs, but also possess the highest density of FoxP3⁺ Tregs. In addition, many of the conventional T cells have a dysfunctional anergic phenotype. In contrast, the non-T cell-inflamed tumors lack these elements but still contain blood vessels, fibroblasts, and macrophages that help support tumor growth. Recruitment of CD8⁺ effector cells is largely dependent on the chemokines CXCL9 and CXCL10, which engage the receptor CXCR3. Treg recruitment is primarily driven by CCL22, which is in part produced by activated CD8⁺ T cells