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. 2019 Aug 7;7:146. doi: 10.3389/fcell.2019.00146

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Copyright © 2019 Mironov and Beznoussenko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme showing the main principles of intracellular transport. (A) The dissociation (mainly vesicular) mode. Initially, membrane buds are formed on a proximal compartment (1) with the help of a protein coat, and then after fission and subsequent uncoating, coat-dependent vesicles move to a distal compartment (2) and are captured by a tethering system (3). Then using SNAREs, the vesicle fuses with the second compartment. (B) The progression mode. Initially a large membrane protrusion is formed from a proximal compartment (1), and it undergoes fission. Then this large carrier is captured by the tethering system (3), and with the help of SNAREs it undergoes fusion with a distal compartment (2). (C) The lateral diffusion mode of intracellular transport between a proximal compartment (1) and a distal compartment (2).