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. 2019 Aug 7;7:146. doi: 10.3389/fcell.2019.00146

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Copyright © 2019 Mironov and Beznoussenko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme of intra-Golgi transport according to the CMPM. The main postulate of this model is that during intra-Golgi transport, the amount of cargo inside the cisterna during its progression is not changed, and that COPI vesicles (COPI, black dots; Golgi-resident proteins, colored dots) should be concentrated in COPI vesicles. (A) Formation of ER-to-Golgi carriers (top). (B) Delivery of ER-to-Golgi carrier to the Golgi complex. (C) Fusion of ER-to-Golgi carriers and formation of the new cis-Golgi cisterna. (D) Formation of COPI-(black dots) coated buds on the Golgi cisternae. (E) Detachment of buds and their uncoating. (F) COPI-dependent vesicles fuse with the proximal Golgi cisternae. (G–I) A new round of cis-cisterna formation, COPI-dependent budding, formation of vesicles, and their uncoating and fusion. (I) Departure of the most-trans cisterna in the form of post-Golgi carriers. (J–N) Additional rounds of similar events. (O) After step-wise departure of the post-Golgi carriers, the cis-Golgi cisterna formed after re-initiation of IGT becomes the trans-cisterna.