Figure 8.

Scheme of intra-Golgi transport according to the KARM. (A–H) Its main principle is the following: initially there is SNARE-dependent fusion with the distal Golgi cisterna, and then fission along the line of the pore row. (I–Q) Scheme showing only two cisternae in three-dimensions. (I) Formation of the cargo domain (red arrow) separated by the row of pores. (J) Fusion the domain with the distal cisterna and enlargement of pores. (K) Break down of two tubules surrounding pores. (L) Break down of the last tubule connecting the domain with the proximal cisterna. (M–Q) Stages of pore formation, when membrane bud grows and then fuses backward to the same cisterna. During the transport wave, there is consumption of the cisternal pores. Images similar to Figure 8B can be found in Trucco et al. (2004) (see their Figures 3l–n).