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. Author manuscript; available in PMC: 2019 Aug 14.
Published in final edited form as: Clin Cancer Res. 2012 May 1;18(13):3603–3615. doi: 10.1158/1078-0432.CCR-11-3321

Figure 4: In vivo effects of MK-2206 and etoposide on tumor growth and mice survival.

Figure 4:

Mice bearing AS, NGP and SY5Y tumors were treated with MK-2206 (200mg/kg) and etoposide (10mg/kg) either alone or in combination. A: Tumor volumes from control and treated groups were compared when the last mouse in each control group was euthanized. Bar, SE. B: Mice survival was compared through Kaplan Meier curves. #P<0.05, ##P<0.01: MK-2206/etoposide-treated group versus MK-2206-treated group. * P<0.05, **P<0.01: MK-2206/etoposide-treated group versus etoposide-treated group. C: NB tumors were harvested at end points, total protein was extracted for analysis of P-Akt, T-Akt, cleaved caspase 3 and GAPDH.